Ara
Toplam kayıt 12, listelenen: 1-10
Comparison of Verona integron-borne metallo-ß-lactamase (VIM) variants reveals differences in stability and inhibition profiles
(2016-03)
Metallo-β-lactamases (MBLs) are of increasing clinical significance; the development of clinically useful MBL inhibitors is challenged by the rapid evolution of variant MBLs. The Verona integron-borne metallo-β-lactamase ...
Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing ß-lactamases in Pseudomonas aeruginosa in Turkey
(2014-03)
Pseudomonas aeruginosa isolates were collected form a Turkish hospital. Antimicrobial susceptibility was performed using the Vitek 2 Compact system, and 24 isolates were categorized as multidrug resistant (n = 18), ...
Effect of amino acid substitution in New Delhi metallo-ß-lactamase on carbapenem susceptibility
(2018-04)
The aim of this work was investigation of clinically important amino acid substitutions of NDM-1 variants. A blaNDM-1 gene was cloned into expression vector pET100/D-TOPO. The sequence of NDM-1 variants with substituted ...
Distribution of ß-lactamase genes among carbapenem-resistant Klebsiella pneumoniae strains isolated from patients in Turkey
(2015-11)
Background
The emergence of carbapenem-resistant Klebsiella pneumoniae poses a serious problem to antibiotic management. We investigated the β-lactamases in a group of carbapenem-resistant K. pneumoniae clinical isolates ...
Determination of a novel integron-located variant (blaOXA-320) of Class D ß-lactamase in Proteus mirabilis
(2014-10)
Proteus mirabilis (P. mirabilis) is one of Gram-negative pathogens encountered in clinical specimens. A clinical isolate (TRP41) of P. mirabilis was isolated from a Turkish patient in Turkey. The isolate was identified ...
Kinetic characterization of GES-22 ß-lactamase harboring the M169L clinical mutation
(2016-12)
The class A β-lactamase GES-22 has been identified in Acinetobacter baumannii isolates in Turkey, and subsequently shown to differ from GES-11 by a single substitution (M169L). Because M169 is part of the omega loop, a ...
Molecular docking analysis and determination of minimum inhibition concentration of VIM-38/R228S.
(2017)
Objective: The aim of this study was to determine the effects of residues at 228th positions of VIM-38 on minimum inhibition concentration (MIC) and molecular docking analysis. Materials and methods: blaVIM-38 gene was ...
Nationwide study of Escherichia coli producing extended-spectrum ß-lactamases TEM, SHV and CTX-M in Turkey
(2013-11)
Four hundred and forty extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolates were collected from 10 different hospitals in Turkey between 2011 and 2012. Clinical specimens consisted of urine (80.45%), ...
Next-generation sequencing of plasmid carrying blaOXA-48 in Klebsiella pneumoniae from Turkey
(2019-02)
A carbapenem-resistant Klebsiella pneumoniae strain was isolated in Turkey in 2012 and blaNDM-1 and blaOXA-48 genes were observed in this strain. The aim of this study was to investigate transferability of plasmid bearing ...
A Novel Integron Gene Cassette Harboring VIM-38 Metallo-ß-lactamase in a Clinical Pseudomonas aeruginosa Isolate
(2016-11)
[Abstract Not Available]