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dc.contributor.authorBalcı, Neslihan
dc.contributor.authorÇelik, Hülya
dc.contributor.authorTürkan, Fikret
dc.contributor.authorÇelebioğlu, Neslihan
dc.contributor.authorÇelik, Tuba
dc.contributor.authorBursal, Ercan
dc.identifier.citationSchiff Base Synthesis with a New Reliable Method and Investigation of Their Inhibition Effects on Glutathione S-Transferase and Cholinesterase Enzymes Neslihan Balcı, Hülya Çelik, Assoc. Prof. Dr. Fikret Türkan, Neslihan Çelebioğlu, Tuba Çelik, Ercan Bursal First published: 10 May 2023
dc.description.abstractThe principle purpose of this study is to synthesize some Schiff base derivatives with a new microwave irradiation technique and investigate their enzyme inhibition effects. Related Schiff base compounds (1 a–1 h) were synthesized from 4-fluoro aniline and some substituted benzaldehyde derivatives (3 a–3 h). The chemical structures of Schiff bases were elucidated by various spectroscopic methods (1H NMR, 13C NMR). The inhibitory effects of the synthesized compounds against acetylcholinesterase, butyrylcholinesterase and glutathione S-transferase were investigated. The in vitro enzyme study determined the best enzyme inhibitors for AChE, BChE, and GST enzymes as 3 h, 3 b, and 3 e compounds, respectively. The results were compared with the standard drugs tacrine for cholinesterase and ethacrynic acid for GST enzymes. Molecular docking results demonstrated the low binding energy values between −5.8 kcal/mol and −8.7 kcal/mol with hydrogen bonding, hydrophilic, and hydrophobic interactions at the active catalytic sites of the enzymes. © 2023 Wiley-VCH GmbH.en_US
dc.publisherJohn Wiley and Sons Incen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectGlutathione S-transferaseen_US
dc.subjectMicrowave irradiationen_US
dc.titleSchiff Base Synthesis with a New Reliable Method and Investigation of Their Inhibition Effects on Glutathione S-Transferase and Cholinesterase Enzymesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.departmentMeslek Yüksekokulları, Şiran Dursun Keleş Sağlık Hizmetleri Meslek Yüksekokulu, Eczane Hizmetleri Bölümüen_US
dc.contributor.institutionauthorBalcı, Neslihan

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