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dc.contributor.authorGülçin, İlhami
dc.contributor.authorTopal, Meryem
dc.date.accessioned2023-02-03T08:27:43Z
dc.date.available2023-02-03T08:27:43Z
dc.date.issued2022en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S187881812200144X?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/20.500.12440/5753
dc.description.abstractIn this study, antidiabetic, anticholinergic, and antioxidant abilities of rosmarinic acid were evaluated and compared to standards. To determine its antioxidant activity different in vitro bioanalytical methods, including total antioxidant activity (TAA), ABTS(center dot+) scavenging activity, O-2(center dot-) scavenging activity, DPPHmiddot scavenging activity, DMPD center dot+ scavenging activity, potassium ferric cyanide reduction ability, cupric ion (Cu2+) reduction capacity, H2O2 scavenging activity, and ferrous ions (Fe2+) binding activities were separately performed. Also, butylated hydroxyanisole (BHA), Trolox, alpha-tocopherol, and butylated hydroxytoluene (BHT) were used as the reference antioxidants. Rosmarinic acid inhibited the linoleic acid emulsion peroxidation by 89.2% while BHA, BHT, Trolox and alpha-tocopherol inhibited as 87.3, 97.6, 90.3 and 75.3%, respectively, at the same concentration (30 mu g/mL). When these results are evaluated, rosmarinic acid had effective TAA than BHA and alpha-tocopherol and close to BHT and Trolox. In addition, rosmarinic acid exhibited K-I values of 9.67 +/- 0.81 nM towards acetylcholinesterase (AChE) and 33.56 +/- 2.96 nM against alpha-glycosidase enzymes.en_US
dc.language.isoengen_US
dc.publisherELSEVIERen_US
dc.relation.ispartofBiocatalysis and Agricultural Biotechnologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectRosmarinic aciden_US
dc.subjectα-Glycosidaseen_US
dc.subjectAntioxidant activityen_US
dc.subjectPhenolic compounden_US
dc.subjectAcetylcholinesteraseen_US
dc.titleEvaluation of the in vitro antioxidant, antidiabetic and anticholinergic properties of rosmarinic acid from rosemary (Rosmarinus officinalis L.)en_US
dc.typearticleen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.description.wospublicationidWOS:000831129700007en_US
dc.departmentMeslek Yüksekokulları, Gümüşhane Sağlık Hizmetleri Meslek Yüksekokulu, Tıbbi Hizmetler ve Teknikler Bölümüen_US
dc.authorid0000-0002-2107-8603en_US
dc.identifier.volume43en_US
dc.contributor.institutionauthorTopal, Meryem
dc.identifier.doi10.1016/j.bcab.2022.102417en_US
dc.authorwosidABG-5541-2021en_US
dc.authorscopusid55929192400en_US


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