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dc.contributor.authorDuong, Angela
dc.contributor.authorChe, Yi
dc.contributor.authorCeylan, Deniz
dc.contributor.authorPinguelo, Arsene
dc.contributor.authorAndreazza, Ana C.
dc.contributor.authorYoung, L. Trevor
dc.contributor.authorBerk, Michael
dc.date.accessioned2021-11-09T19:50:20Z
dc.date.available2021-11-09T19:50:20Z
dc.date.issued2016
dc.identifier.issn0165-1781
dc.identifier.urihttps://doi.org/10.1016/j.psychres.2015.12.015
dc.identifier.urihttps://hdl.handle.net/20.500.12440/4240
dc.description.abstractPhenomenologically, bipolar disorder (BD) is characterized by biphasic increases and decreases in energy. As this is a state-related phenomenon, identifying regulators responsible for this phasic dysregulation has the potential to uncover key elements in the pathophysiology of BD. Given the evidence suggesting mitochondrial complex I dysfunction in BD, we aimed to identify the main regulators of complex I in BD by reviewing the literature and using the published microarray data to examine their gene expression profiles. We also validated protein expression levels of the main complex I regulators by immunohistochemistry. Upon reviewing the literature, we found PARK-7, STAT-3, SIRT-3 and IMP-2 play an important role in regulating complex I activity. Published microarray studies however revealed no significant direction of regulation of STAT-3, SIRT-3, and IMP-2, but a trend towards downregulation of PARK 7 was observed in BD. Immunocontent of DJ-1 (PARK-7-encoded protein) were not elevated in post mortem prefrontal cortex from patients with BD. We also found a trend towards upregulation of DJ-1 expression with age. Our results suggest that DJ-1 is not significantly altered in BD subjects, however further studies are needed to examine DJ-1 expression levels in a cohort of older patients with BD. (C) 2015 Elsevier Ireland Ltd. All rights reserved.en_US
dc.description.sponsorshipNHMRCNational Health and Medical Research Council of Australia [1059660]; Canadian Institutes of Health Research (CIHR)Canadian Institutes of Health Research (CIHR) [133439]; Ontario Mental Health Foundation (OMHF) [498567]; Ministry of Research and Innovation of Canada; CIHRCanadian Institutes of Health Research (CIHR) [133439]en_US
dc.description.sponsorshipWe thank the Stanley Medical Research Institute (SMRI)-Online Genomics Database and Elashoff Consulting, LLC for providing access to the public available microarray data. We also thank Dr. Sabine Bahn, Dr. Tadafumi Kato, Dr. Marquis P. Vawter, Dr. Trevor Young, Dr. Seth E. Dobrin, Dr. Haiming Chen, Dr. Allen A. Fienberg, Dr. Pamela Sklar collaborators from SMRI Online Genomics Database. MB is supported by a NHMRC Senior Principal Research Fellowship 1059660. ACA is supported by Canadian Institutes of Health Research (CIHR 133439), Ontario Mental Health Foundation (OMHF 498567) and Ministry of Research and Innovation of Canada. LTY is supported by CIHR 133439.en_US
dc.language.isoengen_US
dc.publisherElsevier Ireland Ltden_US
dc.relation.ispartofPsychiatry Researchen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBipolar disorderen_US
dc.subjectMitochondrial complex Ien_US
dc.subjectMitochondrial regulatorsen_US
dc.subjectGene expressionen_US
dc.subjectMicroarrayen_US
dc.subjectDJ-1en_US
dc.titleRegulators of mitochondrial complex I activity: A review of literature and evaluation in postmortem prefrontal cortex from patients with bipolar disorderen_US
dc.typearticleen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.description.wospublicationidWOS:000370913900025en_US
dc.departmentGümüşhane Üniversitesien_US
dc.authoridAndreazza, Ana C / 0000-0002-4323-7273
dc.authoridBerk, Michael / 0000-0002-5554-6946
dc.authoridCeylan, Deniz / 0000-0002-1438-8240
dc.authoridBerk, Michael / 0000-0002-5554-6946
dc.authoridDuong, Angela / 0000-0002-5856-3346
dc.identifier.volume236en_US
dc.identifier.startpage148en_US
dc.identifier.doi10.1016/j.psychres.2015.12.015
dc.identifier.endpage157en_US
dc.authorwosidAndreazza, Ana C / P-8562-2018
dc.authorwosidBerk, Michael / M-7891-2013
dc.authorwosidCeylan, Deniz / E-9415-2017
dc.authorwosidBerk, Michael / M-3585-2019
dc.description.pubmedpublicationidPubMed: 26723136en_US


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