dc.contributor.author | Duong, Angela | |
dc.contributor.author | Che, Yi | |
dc.contributor.author | Ceylan, Deniz | |
dc.contributor.author | Pinguelo, Arsene | |
dc.contributor.author | Andreazza, Ana C. | |
dc.contributor.author | Young, L. Trevor | |
dc.contributor.author | Berk, Michael | |
dc.date.accessioned | 2021-11-09T19:50:20Z | |
dc.date.available | 2021-11-09T19:50:20Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0165-1781 | |
dc.identifier.uri | https://doi.org/10.1016/j.psychres.2015.12.015 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12440/4240 | |
dc.description.abstract | Phenomenologically, bipolar disorder (BD) is characterized by biphasic increases and decreases in energy. As this is a state-related phenomenon, identifying regulators responsible for this phasic dysregulation has the potential to uncover key elements in the pathophysiology of BD. Given the evidence suggesting mitochondrial complex I dysfunction in BD, we aimed to identify the main regulators of complex I in BD by reviewing the literature and using the published microarray data to examine their gene expression profiles. We also validated protein expression levels of the main complex I regulators by immunohistochemistry. Upon reviewing the literature, we found PARK-7, STAT-3, SIRT-3 and IMP-2 play an important role in regulating complex I activity. Published microarray studies however revealed no significant direction of regulation of STAT-3, SIRT-3, and IMP-2, but a trend towards downregulation of PARK 7 was observed in BD. Immunocontent of DJ-1 (PARK-7-encoded protein) were not elevated in post mortem prefrontal cortex from patients with BD. We also found a trend towards upregulation of DJ-1 expression with age. Our results suggest that DJ-1 is not significantly altered in BD subjects, however further studies are needed to examine DJ-1 expression levels in a cohort of older patients with BD. (C) 2015 Elsevier Ireland Ltd. All rights reserved. | en_US |
dc.description.sponsorship | NHMRCNational Health and Medical Research Council of Australia [1059660]; Canadian Institutes of Health Research (CIHR)Canadian Institutes of Health Research (CIHR) [133439]; Ontario Mental Health Foundation (OMHF) [498567]; Ministry of Research and Innovation of Canada; CIHRCanadian Institutes of Health Research (CIHR) [133439] | en_US |
dc.description.sponsorship | We thank the Stanley Medical Research Institute (SMRI)-Online Genomics Database and Elashoff Consulting, LLC for providing access to the public available microarray data. We also thank Dr. Sabine Bahn, Dr. Tadafumi Kato, Dr. Marquis P. Vawter, Dr. Trevor Young, Dr. Seth E. Dobrin, Dr. Haiming Chen, Dr. Allen A. Fienberg, Dr. Pamela Sklar collaborators from SMRI Online Genomics Database. MB is supported by a NHMRC Senior Principal Research Fellowship 1059660. ACA is supported by Canadian Institutes of Health Research (CIHR 133439), Ontario Mental Health Foundation (OMHF 498567) and Ministry of Research and Innovation of Canada. LTY is supported by CIHR 133439. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier Ireland Ltd | en_US |
dc.relation.ispartof | Psychiatry Research | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Bipolar disorder | en_US |
dc.subject | Mitochondrial complex I | en_US |
dc.subject | Mitochondrial regulators | en_US |
dc.subject | Gene expression | en_US |
dc.subject | Microarray | en_US |
dc.subject | DJ-1 | en_US |
dc.title | Regulators of mitochondrial complex I activity: A review of literature and evaluation in postmortem prefrontal cortex from patients with bipolar disorder | en_US |
dc.type | article | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.description.wospublicationid | WOS:000370913900025 | en_US |
dc.department | Gümüşhane Üniversitesi | en_US |
dc.authorid | Andreazza, Ana C / 0000-0002-4323-7273 | |
dc.authorid | Berk, Michael / 0000-0002-5554-6946 | |
dc.authorid | Ceylan, Deniz / 0000-0002-1438-8240 | |
dc.authorid | Berk, Michael / 0000-0002-5554-6946 | |
dc.authorid | Duong, Angela / 0000-0002-5856-3346 | |
dc.identifier.volume | 236 | en_US |
dc.identifier.startpage | 148 | en_US |
dc.identifier.doi | 10.1016/j.psychres.2015.12.015 | |
dc.identifier.endpage | 157 | en_US |
dc.authorwosid | Andreazza, Ana C / P-8562-2018 | |
dc.authorwosid | Berk, Michael / M-7891-2013 | |
dc.authorwosid | Ceylan, Deniz / E-9415-2017 | |
dc.authorwosid | Berk, Michael / M-3585-2019 | |
dc.description.pubmedpublicationid | PubMed: 26723136 | en_US |