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dc.contributor.authorMentese, Ahmet
dc.contributor.authorGuven, Suleyman
dc.contributor.authorSumer, Aysegul
dc.contributor.authorTuran, Ibrahim
dc.contributor.authorDemir, Selim
dc.contributor.authorKarahan, Suleyman Caner
dc.contributor.authorAlver, Ahmet
dc.date.accessioned2021-11-09T19:48:48Z
dc.date.available2021-11-09T19:48:48Z
dc.date.issued2013
dc.identifier.issn0250-4685
dc.identifier.urihttps://doi.org/10.5505/tjb.2013.44127
dc.identifier.urihttps://hdl.handle.net/20.500.12440/3807
dc.description.abstractAim: The aim of this study is to investigate anti-carbonic anhydrase antibodies (anti-CA I and CA II antibodies) in the sera of women with polycystic ovary syndrome (PCOS). Methods: In this study serum anti-CA I and II antibody levels of age and BMI matching fifty women with PCOS and fifty women without PCOS on day three of menstrual cycle were assessed with an ELISA method previously developed by Hosoda and modified by Alver et al. Results: The mean serum anti-CA I antibody levels were significantly higher in women with PCOS and anti-CA II antibody levels were not significantly different in women with PCOS compared with control subjects. For serum anti-CA I antibody, the absorbance higher than 0.484 (mean + 3SD of control subjects) was taken as positive, Anti-CA I antibody was detected in 13 of 50 patients with PCOS (26%). Considering serum anti-CA II antibody, the absorbance higher than 0.654 (mean + 3SD of control subjects) was taken as positive. Anti-CA II antibody was detected in 2 of 50 patients with PCOS (4%). All patients with positive anti-CA II antibody also had positive anti-CA I antibody. Autoantibodies specifically reactive to CA I were found to be present at a higher frequency than CA II in the serum of subjects with PCOS in the present study. Conclusion: The results may suggest that autoimmune responses against CA I may be involved in the pathogenesis of PCOS.en_US
dc.language.isoengen_US
dc.publisherTurkish Biochem Socen_US
dc.relation.ispartofTurkish Journal of Biochemistry-Turk Biyokimya Dergisien_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectautoantibodyen_US
dc.subjectcarbonic anhydrase Ien_US
dc.subjectcarbonic anhydrase IIen_US
dc.subjectpolycystic ovary syndromeen_US
dc.titleSerum anti-carbonic anhydrase I and II antibodies and polycystic ovary syndromeen_US
dc.typearticleen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.description.wospublicationidWOS:000323180100008en_US
dc.description.scopuspublicationid2-s2.0-84877092231en_US
dc.departmentGümüşhane Üniversitesien_US
dc.authoridDemir, Selim / 0000-0002-1863-6280
dc.authoridGuven, Suleyman / 0000-0003-4832-4525
dc.authoridALVER, AHMET / 0000-0002-9617-6689
dc.identifier.volume38en_US
dc.identifier.issue1en_US
dc.identifier.startpage43en_US
dc.identifier.doi10.5505/tjb.2013.44127
dc.identifier.endpage48en_US
dc.authorwosidDemir, Selim / AAR-2241-2020
dc.authorwosidKarahan, Suleyman Caner / AAL-5846-2021
dc.authorwosidGuven, Suleyman / F-8848-2012
dc.authorwosidMentese, Ahmet / AAT-2342-2020
dc.authorwosidALVER, AHMET / AAH-4599-2021
dc.authorwosidTuran, Ibrahim / ABI-5207-2020
dc.authorwosidDemir, Selim / AAE-8473-2020
dc.authorscopusid23489347700
dc.authorscopusid56244707700
dc.authorscopusid55332611400
dc.authorscopusid36904580100
dc.authorscopusid55674801800
dc.authorscopusid6701582693
dc.authorscopusid55927131100


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