In vitro inhibition of a-carbonic anhydrase isozymes by some phenolic compounds

dc.contributor.author	Topal, Fevzi
dc.date.accessioned	2014-09-15T12:45:54Z
dc.date.available	2014-09-15T12:45:54Z
dc.date.issued	2011
dc.identifier.uri	https://hdl.handle.net/20.500.12440/326
dc.description.abstract	Carbonic anhydrase inhibitors (CAIs) are a class of pharmaceuticals used as antiglaucoma agents, diuret-ics, antiepileptics, in the management of mountain sickness, gastric and duodenal ulcers, neurological disorders or osteoporosis. We report here the inhibitory capacities of some phenolic compounds against three human CA isozymes (hCA I, hCA II, and hCA VI) and the gill carbonic anhydrase of the teleost fish Dicentrarchus labrax (European seabass) (dCA). The isozymes showed quite diverse inhibition profiles with these compounds. These data may lead to design novel CAIs with a diverse inhibition mechanism compared to sulfonamide/sulfamate inhibitors.	en_US
dc.language.iso	eng	en_US
dc.rights	info:eu-repo/semantics/restrictedAccess	en_US
dc.subject	Tannic acid Pyrogallol Carbonic anhydrase Inhibition hCA-I hCA-II hCA VI dCA Antiglaucoma	en_US
dc.title	In vitro inhibition of a-carbonic anhydrase isozymes by some phenolic compounds	en_US
dc.type	article	en_US
dc.relation.publicationcategory	Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı	en_US
dc.department	Meslek Yüksekokulları, Gümüşhane Meslek Yüksekokulu, Kimya ve Kimyasal İşleme Teknolojileri Bölümü	en_US
dc.contributor.institutionauthor	Topal, Fevzi