ORCID "GULCIN, Ilhami / 0000-0001-5993-1668" için listeleme
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9,10-Dibromo-N-aryl-9,10-dihydro-9,10-[3,4]epipyrroloanthracene-12,14-diones: Synthesis and Investigation of Their Effects on Carbonic Anhydrase Isozymes I, II, IX, and XII
Goksu, Haydar; Topal, Meryem; Keskin, Ali; Gultekin, Mehmet S.; Celik, Murat; Gulcin, Ilhami; Supuran, Claudiu T. (Wiley-V C H Verlag Gmbh, 2016)N-substituted maleimides were synthesized from maleic anhydride and primary amines. 1,4-Dibromodibenzo[e,h]bicyclo-[2,2,2]octane-2,3-dicarboximide derivatives (4a-f) were prepared by the [4+2] cycloaddition reaction of ... -
Acetylcholinesterase and carbonic anhydrase isoenzymes I and II inhibition profiles of taxifolin
Gocer, Hulya; Topal, Fevzi; Topal, Meryem; Kucuk, Murat; Teke, Dilek; Gulcin, Ilhami; Supuran, Claudiu T. (Taylor & Francis Ltd, 2016)Taxifolin, also known as dihydroquercetin, is a flavonoid commonly found in plants. Carbonic anhydrase (CA, EC 4.2.1.1) plays an important role in many critical physiological events including carbon dioxide (CO2)/bicarbonate ... -
Anticholinergic, antidiabetic and antioxidant activities of cinnamon (cinnamomum verum) bark extracts: polyphenol contents analysis by LC-MS/MS
Gulcin, Ilhami; Kaya, Ruya; Goren, Ahmet C.; Akincioglu, Hulya; Topal, Meryem; Bingol, Zeynebe; Alwasel, Saleh (Taylor & Francis Inc, 2019)Ethanolic (EEC) and aqueous (WEC) extracts of cinnamon (Cinnamomum verum) were evaluated for their antioxidant profiles by eight distinguished bioanalytical antioxidant methods. Their inhibitory effects were tested against ... -
Antioxidant activity of taxifolin: an activity-structure relationship
Topal, Fevzi; Nar, Meryem; Gocer, Hulya; Kalin, Pinar; Kocyigit, Umit M.; Gulcin, Ilhami; Alwasel, Saleh H. (Taylor & Francis Ltd, 2016)Taxifolin is a kind of flavanonol, whose biological ability. The objectives of this study were to investigate the antioxidants and antiradical activities of taxifolin by using different in vitro bioanalytical antioxidant ... -
Antioxidant, antiradical, and anticholinergic properties of cynarin purified from the Illyrian thistle (Onopordum illyricum L.)
Topal, Meryem; Gocer, Hulya; Topal, Fevzi; Kalin, Pinar; Kose, Leyla Polat; Gulcin, Ilhami; Alwasel, Saleh H. (Taylor & Francis Ltd, 2016)Cynarin is a derivative of hydroxycinnamic acid and it has biologically active functional groups constituent of some plants and food. We elucidated the antioxidant activity of cynarin by using different in vitro condition ... -
In vitro inhibition of alpha-carbonic anhydrase isozymes by some phenolic compounds
Sarikaya, Sevim Beyza Ozturk; Topal, Fevzi; Senturk, Murat; Gulcin, Ilhami; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2011)Carbonic anhydrase inhibitors (CAIs) are a class of pharmaceuticals used as antiglaucoma agents, diuretics, antiepileptics, in the management of mountain sickness, gastric and duodenal ulcers, neurological disorders or ... -
Inhibition profile of a series of phenolic acids on bovine lactoperoxidase enzyme
Sarikaya, S. Beyza Ozturk; Sisecioglu, Melda; Cankaya, Murat; Gulcin, Ilhami; Ozdemir, Hasan (Taylor & Francis Ltd, 2015)Lactoperoxidase (LPO) catalyzes the oxidation of numerous of organic and inorganic substrates by hydrogen peroxide. It has very vital activity in the innate immune system by decreasing or stopping the activation of the ... -
N-Acylsulfonamides strongly inhibit human carbonic anhydrase isoenzymes I and II
Yildirim, Alper; Atmaca, Ufuk; Keskin, Ali; Topal, Meryem; Celik, Murat; Gulcin, Ilhami; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2015)Sulfonamides represent a significant class of biologically active compounds that inhibit carbonic anhydrase (CA, EC.: 4.2.1.1) isoenzymes involved in different pathological and physiological events. Sulfonamide CA inhibitors ... -
Novel eugenol derivatives: Potent acetylcholinesterase and carbonic anhydrase inhibitors
Topal, Fevzi; Gulcin, Ilhami; Dastan, Arif; Guney, Murat (Elsevier Science Bv, 2017)Eugenol was used as starting material to obtain some phenolic compounds. The synthesis of these phenolic compounds was performed in a two-step procedure. The structures of the formed products (novel eugenol derivatives ... -
Oxidation of cyanobenzocycloheptatrienes: Synthesis, photooxygenation reaction and carbonic anhydrase isoenzymes inhibition properties of some new benzotropone derivatives
Guney, Murat; Coskun, Ahmet; Topal, Fevzi; Dastan, Arif; Gulcin, Ilhami; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2014)The oxidation of some cyanocycloheptatrienes with CrO3 and pyridine was investigated and a few new nitrile functionalised benzotropone derivatives were obtained. Photooxygenation reaction of these products was also studied. ... -
Polyphenol Contents and Antioxidant Properties of Medlar (Mespilus germanica L.)
Gulcin, Ilhami; Topal, Fevzi; Sarikaya, S. Beyza Ozturk; Bursal, Ercan; Bilsel, Gokhan; Goren, Ahmet C. (Acg Publications, 2011)Medlar is the fruit of Mespilus germanica L. in the family of Rosaceae. The present study outlines that the native medlar (Mespilus germanica L.) fruits an extremely rich source of antioxidants. In this study, antioxidant ... -
Purification and selected biochemical properties of peroxidase from cress (Lepidium sativum sub sp sativum)
Altay, Ahmet; Koktepe, Tubanur; Durmaz, Lokman; Topal, Fevzi; Gulcin, Ilhami; Koksal, Ekrem (Taylor & Francis Inc, 2018)Cress (Lepidium sativum) is an annual herb from Brassicaceae family, and in some regions. It is known as peppergrass, garden cress, garden peppercress, pepperwort, or poor man's pepper. Cress is an important medicinal plant ... -
Synthesis and Carbonic Anhydrase Inhibitory Effects of Novel Sulfamides Derived from 1-Aminoindanes and Anilines
Akbaba, Yusuf; Bastem, Enes; Topal, Fevzi; Gulcin, Ilhami; Maras, Ahmet; Goksu, Suleyman (Wiley-V C H Verlag Gmbh, 2014)Three 1-aminoindanes, four anilines and BnOH or t-BuOH were reacted with chlorosulfonyl isocyanate to give sulfamoyl carbamates. Pd-C catalysed hydrogenolysis reactions of carbamates or deprotection of the Boc group of the ...