Yazar "Topal, Meryem" için listeleme
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9,10-Dibromo-N-aryl-9,10-dihydro-9,10-[3,4]epipyrroloanthracene-12,14-diones: Synthesis and Investigation of Their Effects on Carbonic Anhydrase Isozymes I, II, IX, and XII
Goksu, Haydar; Topal, Meryem; Keskin, Ali; Gultekin, Mehmet S.; Celik, Murat; Gulcin, Ilhami; Supuran, Claudiu T. (Wiley-V C H Verlag Gmbh, 2016)N-substituted maleimides were synthesized from maleic anhydride and primary amines. 1,4-Dibromodibenzo[e,h]bicyclo-[2,2,2]octane-2,3-dicarboximide derivatives (4a-f) were prepared by the [4+2] cycloaddition reaction of ... -
Acetylcholinesterase and carbonic anhydrase isoenzymes I and II inhibition profiles of taxifolin
Gocer, Hulya; Topal, Fevzi; Topal, Meryem; Kucuk, Murat; Teke, Dilek; Gulcin, Ilhami; Supuran, Claudiu T. (Taylor & Francis Ltd, 2016)Taxifolin, also known as dihydroquercetin, is a flavonoid commonly found in plants. Carbonic anhydrase (CA, EC 4.2.1.1) plays an important role in many critical physiological events including carbon dioxide (CO2)/bicarbonate ... -
Anticholinergic, antidiabetic and antioxidant activities of cinnamon (cinnamomum verum) bark extracts: polyphenol contents analysis by LC-MS/MS
Gulcin, Ilhami; Kaya, Ruya; Goren, Ahmet C.; Akincioglu, Hulya; Topal, Meryem; Bingol, Zeynebe; Alwasel, Saleh (Taylor & Francis Inc, 2019)Ethanolic (EEC) and aqueous (WEC) extracts of cinnamon (Cinnamomum verum) were evaluated for their antioxidant profiles by eight distinguished bioanalytical antioxidant methods. Their inhibitory effects were tested against ... -
Antidiabetic, anticholinergic and antioxidant activities of aerial parts of shaggy bindweed (Convulvulus betonicifolia Miller subsp.) - profiling of phenolic compounds by LC-HRMS
Bingol, Zeynebe; Kiziltas, Hatice; Goren, Ahmet C.; Kose, Leyla Polat; Topal, Meryem; Durmaz, Lokman; Gulcin, Ilhami (Elsevier Sci Ltd, 2021)In order to evaluate the antioxidant activity of evaporated ethanolic extract (EESB) and lyophilized water extract (WESB) of Shaggy bindweed (Convulvulus betonicifolia Mill. Subs), some putative antioxidant methods such ... -
Antioxidant, antiradical, and anticholinergic properties of cynarin purified from the Illyrian thistle (Onopordum illyricum L.)
Topal, Meryem; Gocer, Hulya; Topal, Fevzi; Kalin, Pinar; Kose, Leyla Polat; Gulcin, Ilhami; Alwasel, Saleh H. (Taylor & Francis Ltd, 2016)Cynarin is a derivative of hydroxycinnamic acid and it has biologically active functional groups constituent of some plants and food. We elucidated the antioxidant activity of cynarin by using different in vitro condition ... -
Determination of Angelica archangelica's Antioxidant Capacity and Mineral Content
Topal, Meryem; Ozturk Sarikaya, S. Beyza; Topal, Fevzi (Wiley-V C H Verlag Gmbh, 2021)The aim of this study was to determine the mineral contents by ICP-MS and the antioxidant capacity of Angelica archangelica plant, which is not well known in the literature. For this purpose, ethyl alcohol extracts of the ... -
Determination of antioxidant and antiradical properties of Picea orientalis cone
Topal, Meryem (2018)Structural degradation of DNA, proteins, carbohydrates and lipids occurs as long as the reactive oxygen species formed in metabolism are not inhibited. As a result, both the stabilization and the function of the cell ... -
Determination of the Antioxidant Capacity of Puerarin and Its Effect on Cholinesterases by in vitro and in silico Methods
İnan Ergün, Aslı; Topal, Meryem (John Wiley and Sons Inc, 2023)Puerarin, which was used as a natural isoflavone in this study, was obtained from the Kudzu plant. The inhibitory effect of puerarin on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes was investigated. ... -
Evaluation of the in vitro antioxidant, antidiabetic and anticholinergic properties of rosmarinic acid from rosemary (Rosmarinus officinalis L.)
Gülçin, İlhami; Topal, Meryem (ELSEVIER, 2022)In this study, antidiabetic, anticholinergic, and antioxidant abilities of rosmarinic acid were evaluated and compared to standards. To determine its antioxidant activity different in vitro bioanalytical methods, including ... -
The inhibition profile of sesamol against alpha-glycosidase and acetylcholinesterase enzymes
Topal, Meryem (Taylor & Francis Inc, 2019)Sesamol (1,3-benzodioxol-5-ol) is found in the oilseed product, sesame. In our study, the inhibitory effects of sesamol compound on acetylcholinesterase and alpha-glycosidase enzymes were evaluated. Another aim of this ... -
LC-HRMS Profiling and Phenolic Content, Cholinesterase, and Antioxidant Activities of Terminalia citrina
Ebubekir Özler; Fevzi Topal; Meryem Topal; Sevim Beyza Öztürk Sarıkaya (WILEY, 2023)Terminalia citrina (T. citrina) belongs to the Combretaceae family and is included in the class of medicinal plants in tropical countries such as Bangladesh, Myanmar, and India. The antioxidant activities of lyophilized ... -
N-Acylsulfonamides strongly inhibit human carbonic anhydrase isoenzymes I and II
Yildirim, Alper; Atmaca, Ufuk; Keskin, Ali; Topal, Meryem; Celik, Murat; Gulcin, Ilhami; Supuran, Claudiu T. (Pergamon-Elsevier Science Ltd, 2015)Sulfonamides represent a significant class of biologically active compounds that inhibit carbonic anhydrase (CA, EC.: 4.2.1.1) isoenzymes involved in different pathological and physiological events. Sulfonamide CA inhibitors ... -
Novel asymmetric biscarbothioamides as Alzheimer's disease associated cholinesterase inhibitors: synthesis, biological activity, and molecular docking studies
Muǧlu, Halit; Yakan, Hasan; Erdoğan, Musa; Topal, Fevzi; Topal, Meryem (Royal Society of Chemistry, 3 June 202)Exploring novel frameworks for treating Alzheimer's disease is an ambitious objective. In this particular context, a range of asymmetric biscarbothioamide derivatives (3a-l) with varying substitutions have been meticulously ... -
Novel Sulphamides and Sulphonamides Incorporating the Tetralin Scaffold as Carbonic Anhydrase and Acetylcholine Esterase Inhibitors
Topal, Meryem (2013-09-17)Reactions of amino, aminomethyl tetralins and benzyl alcohol with chlorosulphonyl isocyanate (CSI) afforded sulphamoyl carbamates. The sulphamoyl carbamates were converted to sulphamides by palladium-catalysed hydrogenolysis. ... -
Rosmarinic acid: a potent carbonic anhydrase isoenzymes inhibitor
Topal, Meryem (2014-08-15)Rosmarinic acid is a water-soluble ester of ca eic acid and 3,4-dihydroxyphenyllactic acids, and is mainly found in plant species including Boraginaceae and Lamiaceae. In this research, we determined the inhibition property ... -
Secondary Metabolites of Ethanol Extracts of Pinus sylvestris Cones from Eastern Anatolia and Their Antioxidant, Cholinesterase and alpha-Glucosidase Activities
Topal, Meryem (Acg Publications, 2020)Scots pine (Pinus sylvestris) is the most widely distributed tree species among pine species. Antiradical, antioxidant properties and inhibition properties on butyrylcholinesterase (BChE), acetylcholinesterase (AChE) and ... -
Synthesis of some natural sulphonamide derivatives as carbonic anhydrase inhibitors
Gokcen, Taner; Al, Melike; Topal, Meryem; Gulcin, Ilhami; Ozturk, Turan; Goren, Ahmet C. (Acg Publications, 2017)Carbonic anhydrase inhibitor; sulphonamides; p-hydroxybenzoic acid; 3,4,5-trihydroxybenzoic acid (gallic acid).Carbonic anhydrase inhibitors are both in clinical use as antiglaucoma, diuretics, antiepileptics and management ...
