Yazar "Saral, Ayşegül" için listeleme
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Antibacterial Activity of DMSO Extracts of Selected Plants Against Antibiotic Resistant Clinical Isolates
Saral, Ayşegül; Kardil, Uğur; Düzgün, Azer Özad (2019)In this study, we aimed to find out new herbal materials that are able to inhibit the growth of the P. aeruginosa and E.coli clinical isolates that has antibiotic resistance. Clinical isolates used in this research are E. ... -
Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing ß-lactamases in Pseudomonas aeruginosa in Turkey
Iraz, Meryem; Özad Düzgün, Azer; Çopur Çiçek, Ayşegül; Bonnin, Remy A.; Ceylan, Ayşenur; Saral, Ayşegül; Nordmann, Patrice; Sandallı, Cemal (2014-03)Pseudomonas aeruginosa isolates were collected form a Turkish hospital. Antimicrobial susceptibility was performed using the Vitek 2 Compact system, and 24 isolates were categorized as multidrug resistant (n = 18), ... -
Comparison of Verona integron-borne metallo-ß-lactamase (VIM) variants reveals differences in stability and inhibition profiles
Makena, Anne; Özad Düzgün, Azer; Brem, Jürgen; McDonough, Michael A; Rydzik, Anna M; Abboud, Martine I; Saral, Ayşegül; Çopur Çiçek, Ayşegül; Sandallı, Cemal; Schofield, Christopher J (2016-03)Metallo-β-lactamases (MBLs) are of increasing clinical significance; the development of clinically useful MBL inhibitors is challenged by the rapid evolution of variant MBLs. The Verona integron-borne metallo-β-lactamase ... -
Çoklu-İlaç Dirençli P. aeruginosa ve E. coli Suşlarında Antibiyotik Direnç Genlerinin ve Sınıf 1 İntegron Gen Kasetlerinin Araştırılması
Özad Düzgün, Azer; Saral, Ayşegül (2018)P. aeruginosa ve E.coli izolatlarının birçok antibiyotiğe direnç kazanması nedeniyle bu patojenlerin neden olduğu enfeksiyonların tedavisi zorlaşmıştır. Bundan dolayı klinik izolatlarda antibiyotik direnç genlerinin ... -
Determination of a novel integron-located variant (blaOXA-320) of Class D ß-lactamase in Proteus mirabilis
Proteus mirabilis (P. mirabilis) is one of Gram-negative pathogens encountered in clinical specimens. A clinical isolate (TRP41) of P. mirabilis was isolated from a Turkish patient in Turkey. The isolate was identified ... -
Distribution of ß-lactamase genes among carbapenem-resistant Klebsiella pneumoniae strains isolated from patients in Turkey
Iraz, Meryem; Özad Düzgün, Azer; Sandallı, Cemal; Doymaz, Mehmet Ziya; Akkoyunlu, Yasemin; Saral, Ayşegül; Peleg, Anton Y.; Özgümüş, Osman Birol; Beriş, Fatih Şaban; Karaoğlu, Hakan; Çopur Çiçek, Ayşegül (2015-11)Background The emergence of carbapenem-resistant Klebsiella pneumoniae poses a serious problem to antibiotic management. We investigated the β-lactamases in a group of carbapenem-resistant K. pneumoniae clinical isolates ... -
Investigation of Antibiotic Resistance Genes and Class 1 Integron in Multi-Drug Resistant P. aeruginosa and E. coli Strains
Düzgün, Azer Özad; Saral, Ayşegül (2018)P. aeruginosa and E. coli are resistant to many antibiotics, so the treatment of infections of these pathogens has become difficult. Therefore, searching for the presence of antibiotic resistance genes in clinical isolates ... -
Kinetic characterization of GES-22 ß-lactamase harboring the M169L clinical mutation
Saral, Ayşegül; Leonard, David A; Özad Düzgün, Azer; Çopur Çiçek, Ayşegül; June, Cynthia M; Sandallı, Cemal (2016-12)The class A β-lactamase GES-22 has been identified in Acinetobacter baumannii isolates in Turkey, and subsequently shown to differ from GES-11 by a single substitution (M169L). Because M169 is part of the omega loop, a ... -
Klinik E.coli İzolatlarında Virülans Faktör Genlerinin ve Genişlemiş Spektrumlu Beta Laktamazların Araştırılması
Bu çalışmanın amacı, 83 klinik E.coli izolatında pap, hly, cnf, sfa, aer ve afa virulans genlerinin ve genişlemiş spektrumlu beta laktamaz direnç genlerinin varlığını araştırmaktır. Antibiyotik duyarlılık testi için 17 ... -
Molecular docking analysis and determination of minimum inhibition concentration of VIM-38/R228S.
Özad Düzgün, Azer; Saral, Ayşegül (2017)Objective: The aim of this study was to determine the effects of residues at 228th positions of VIM-38 on minimum inhibition concentration (MIC) and molecular docking analysis. Materials and methods: blaVIM-38 gene was ... -
Nationwide study of Escherichia coli producing extended-spectrum ß-lactamases TEM, SHV and CTX-M in Turkey
Çopur Çiçek, Ayşegül; Saral, Ayşegül; Özad Düzgün, Azer; Yaşar, Ekrem; Çizmeci, Zeynep; Balcı, Pervin Özlem; Sarı, Fatma; Fırat, Mehmet; Ay Altıntop, Yasemin; Ak, Sibel; Çalışkan, Ahmet; Yıldız, Nazan; Sancaktar, Metin; Budak, Emine Esra (2013-11)Four hundred and forty extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolates were collected from 10 different hospitals in Turkey between 2011 and 2012. Clinical specimens consisted of urine (80.45%), ... -
Next-generation sequencing of plasmid carrying blaOXA-48 in Klebsiella pneumoniae from Turkey
Özad Düzgün, Azer; Saral, Ayşegül (2019-02)A carbapenem-resistant Klebsiella pneumoniae strain was isolated in Turkey in 2012 and blaNDM-1 and blaOXA-48 genes were observed in this strain. The aim of this study was to investigate transferability of plasmid bearing ... -
OXA- and GES-type ß-lactamases predominate in extensively drug-resistant Acinetobacter baumannii isolates from a Turkish University Hospital
Çopur Çiçek, Ayşegül; Saral, Ayşegül; Iraz, Meryem; Ceylan, Ayşenur; Özad Düzgün, Azer; Peleg, Anton Y.; Sandallı, Cemal (2014-05-01)We determined the antibiotic susceptibility and genetic mechanisms of resistance in clinical strains of Acinetobacter baumannii from Istanbul, Turkey. A total of 101 clinical strains were collected between November 2011 ... -
Screening of Class 1 and Class 2 integrons in clinical isolates of Pseudomonas aeruginosa collected from seven hospitals in Turkey: A multicenter study
Çopur Çiçek, Ayşegül; Saral, Ayşegül; Özad Düzgün, Azer; Çizmeci, Zeynep; Kayman, Tuba; Balcı, Pervin Özlem; Dal, Tuba; Fırat, Mehmet; Yazıcı, Yelda; Sancaktar, Metin; Özgümüş, Osman Birol; Sandallı, Cemal (2013-12)Pseudomonas aeruginosa is one of the leading nosocomial pathogens worldwide, and their infections are difficult to treat due to acquired resistance to many antibiotics. This study aimed to detect class 1 and 2 integrons ...
