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Apoptotic, antioxidant and antiradical effects of majdine and isomajdine from Vinca herbacea Waldst. and kit
Topal, Fevzi; Gülçin, İlhami; Beydemir, Şükrü; Gagua, Natia; Bakuridze, Aliko; Bayram, Recep; Gepdiremen, Akçahan (2012)herbacea Waldst. and Kit were studied. For testing the possible apoptotic effects of majdine and isomajdine from V. herbacea, DNA fragmentation assay was conducted on the rat brain cortical tissue homogenates, in vitro. ... -
Sulfonamide-Bearing Pyrazolone Derivatives as Multitarget Therapeutic Agents: Design, Synthesis, Characterization, Biological Evaluation, In Silico ADME/T Profiling and Molecular Docking Study
Lolak, Nebih; Akocak, Suleyman; Topal, Meryem; Koçyiğit, Ümit Muhammet; Işık, Mesut; Türkeş, Cüneyt; Topal, Fevzi; Durgun, Mustafa; Beydemir, Şükrü (John Wiley and Sons Inc, April 2025)The research and design of new inhibitors for the treatment of diseases such as Alzheimer's disease and glaucoma through inhibition of cholinesterases (ChEs; acetylcholinesterase, AChE and butyrylcholinesterase, BChE) and ...