Yazar "Özad Düzgün, Azer" için listeleme
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Characterization of novel VIM carbapenemase, VIM-38, and first detection of GES-5 carbapenem-hydrolyzing ß-lactamases in Pseudomonas aeruginosa in Turkey
Iraz, Meryem; Özad Düzgün, Azer; Çopur Çiçek, Ayşegül; Bonnin, Remy A.; Ceylan, Ayşenur; Saral, Ayşegül; Nordmann, Patrice; Sandallı, Cemal (2014-03)Pseudomonas aeruginosa isolates were collected form a Turkish hospital. Antimicrobial susceptibility was performed using the Vitek 2 Compact system, and 24 isolates were categorized as multidrug resistant (n = 18), ... -
Comparison of Verona integron-borne metallo-ß-lactamase (VIM) variants reveals differences in stability and inhibition profiles
Makena, Anne; Özad Düzgün, Azer; Brem, Jürgen; McDonough, Michael A; Rydzik, Anna M; Abboud, Martine I; Saral, Ayşegül; Çopur Çiçek, Ayşegül; Sandallı, Cemal; Schofield, Christopher J (2016-03)Metallo-β-lactamases (MBLs) are of increasing clinical significance; the development of clinically useful MBL inhibitors is challenged by the rapid evolution of variant MBLs. The Verona integron-borne metallo-β-lactamase ... -
Çoklu-İlaç Dirençli P. aeruginosa ve E. coli Suşlarında Antibiyotik Direnç Genlerinin ve Sınıf 1 İntegron Gen Kasetlerinin Araştırılması
Özad Düzgün, Azer; Saral, Ayşegül (2018)P. aeruginosa ve E.coli izolatlarının birçok antibiyotiğe direnç kazanması nedeniyle bu patojenlerin neden olduğu enfeksiyonların tedavisi zorlaşmıştır. Bundan dolayı klinik izolatlarda antibiyotik direnç genlerinin ... -
Detection of virulence factor genes, antibiotic resistance genes and biofilm formation in clinical Gram-negative bacteria and first report from Türkiye of K.oxytoca carrying both bla OXA-23 and bla OXA-51 genes
Özad Düzgün, Azer; Yüksel, Gamze (Springer Science and Business Media, 2023)The Gram-negative bacteria were isolated from various samples and antibiotic susceptibility testing were performed. The strains were screened by PCR for class 1 integron, virulence and antibiotic resistance genes. blaOXA-23 ... -
Determination of a novel integron-located variant (blaOXA-320) of Class D ß-lactamase in Proteus mirabilis
Proteus mirabilis (P. mirabilis) is one of Gram-negative pathogens encountered in clinical specimens. A clinical isolate (TRP41) of P. mirabilis was isolated from a Turkish patient in Turkey. The isolate was identified ... -
Determination of the Cytotoxicity and Antibiofilm Potential Effect of Equisetum arvense Silver Nanoparticles
Akar, Zeynep; Akay, Seref; Ejder, Nebahat; Özad Düzgün, Azer (Springer, 2023)This study aimed to synthesize and characterize silver nanoparticles (AgNPs) by green synthesis from Equisetum arvense (Ea) extracts and to investigate their cytotoxicity, antibiofilm activity, and α-glucosidase enzyme ... -
Distribution of ß-lactamase genes among carbapenem-resistant Klebsiella pneumoniae strains isolated from patients in Turkey
Iraz, Meryem; Özad Düzgün, Azer; Sandallı, Cemal; Doymaz, Mehmet Ziya; Akkoyunlu, Yasemin; Saral, Ayşegül; Peleg, Anton Y.; Özgümüş, Osman Birol; Beriş, Fatih Şaban; Karaoğlu, Hakan; Çopur Çiçek, Ayşegül (2015-11)Background The emergence of carbapenem-resistant Klebsiella pneumoniae poses a serious problem to antibiotic management. We investigated the β-lactamases in a group of carbapenem-resistant K. pneumoniae clinical isolates ... -
Effect of amino acid substitution in New Delhi metallo-ß-lactamase on carbapenem susceptibility
Özad Düzgün, Azer (2018-04)The aim of this work was investigation of clinically important amino acid substitutions of NDM-1 variants. A blaNDM-1 gene was cloned into expression vector pET100/D-TOPO. The sequence of NDM-1 variants with substituted ... -
Investigation of Antibiofilm and Antibacterial Properties of Green Synthesized Silver Nanoparticles from Aqueous Extract of Rumex sp.
Akay, Seref; Yüksel, Gamze; Özad Düzgün, Azer (Springer, 2023)The decrease in the effectiveness of conventional drugs as a result of the growth of resistance to antibiotics has increased the need for innovative tools to control the infections. At this point, metallic nanoparticles, ... -
Kinetic characterization of GES-22 ß-lactamase harboring the M169L clinical mutation
Saral, Ayşegül; Leonard, David A; Özad Düzgün, Azer; Çopur Çiçek, Ayşegül; June, Cynthia M; Sandallı, Cemal (2016-12)The class A β-lactamase GES-22 has been identified in Acinetobacter baumannii isolates in Turkey, and subsequently shown to differ from GES-11 by a single substitution (M169L). Because M169 is part of the omega loop, a ... -
Molecular docking analysis and determination of minimum inhibition concentration of VIM-38/R228S.
Özad Düzgün, Azer; Saral, Ayşegül (2017)Objective: The aim of this study was to determine the effects of residues at 228th positions of VIM-38 on minimum inhibition concentration (MIC) and molecular docking analysis. Materials and methods: blaVIM-38 gene was ... -
Nationwide study of Escherichia coli producing extended-spectrum ß-lactamases TEM, SHV and CTX-M in Turkey
Çopur Çiçek, Ayşegül; Saral, Ayşegül; Özad Düzgün, Azer; Yaşar, Ekrem; Çizmeci, Zeynep; Balcı, Pervin Özlem; Sarı, Fatma; Fırat, Mehmet; Ay Altıntop, Yasemin; Ak, Sibel; Çalışkan, Ahmet; Yıldız, Nazan; Sancaktar, Metin; Budak, Emine Esra (2013-11)Four hundred and forty extended-spectrum β-lactamase (ESBL)-producing Escherichia coli isolates were collected from 10 different hospitals in Turkey between 2011 and 2012. Clinical specimens consisted of urine (80.45%), ... -
Next-generation sequencing of plasmid carrying blaOXA-48 in Klebsiella pneumoniae from Turkey
Özad Düzgün, Azer; Saral, Ayşegül (2019-02)A carbapenem-resistant Klebsiella pneumoniae strain was isolated in Turkey in 2012 and blaNDM-1 and blaOXA-48 genes were observed in this strain. The aim of this study was to investigate transferability of plasmid bearing ... -
OXA- and GES-type ß-lactamases predominate in extensively drug-resistant Acinetobacter baumannii isolates from a Turkish University Hospital
Çopur Çiçek, Ayşegül; Saral, Ayşegül; Iraz, Meryem; Ceylan, Ayşenur; Özad Düzgün, Azer; Peleg, Anton Y.; Sandallı, Cemal (2014-05-01)We determined the antibiotic susceptibility and genetic mechanisms of resistance in clinical strains of Acinetobacter baumannii from Istanbul, Turkey. A total of 101 clinical strains were collected between November 2011 ... -
Screening of Class 1 and Class 2 integrons in clinical isolates of Pseudomonas aeruginosa collected from seven hospitals in Turkey: A multicenter study
Çopur Çiçek, Ayşegül; Saral, Ayşegül; Özad Düzgün, Azer; Çizmeci, Zeynep; Kayman, Tuba; Balcı, Pervin Özlem; Dal, Tuba; Fırat, Mehmet; Yazıcı, Yelda; Sancaktar, Metin; Özgümüş, Osman Birol; Sandallı, Cemal (2013-12)Pseudomonas aeruginosa is one of the leading nosocomial pathogens worldwide, and their infections are difficult to treat due to acquired resistance to many antibiotics. This study aimed to detect class 1 and 2 integrons ...
