Gelişmiş Arama

Basit öğe kaydını göster

dc.contributor.authorBereketoglu, Ceyhun
dc.contributor.authorArga, Kazim Yalcin
dc.contributor.authorEraslan, Serpil
dc.contributor.authorMertoglu, Bulent
dc.date.accessioned2021-11-09T19:48:53Z
dc.date.available2021-11-09T19:48:53Z
dc.date.issued2017
dc.identifier.issn1094-8341
dc.identifier.issn1531-2267
dc.identifier.urihttps://doi.org/10.1152/physiolgenomics.00034.2017
dc.identifier.urihttps://hdl.handle.net/20.500.12440/3853
dc.description.abstractBioaccumulative environmental estrogen, nonylphenol (NP; 4-nonylphenol), is widely used as a nonionic surfactant and can affect human health. Since genomes of Saccharomyces cerevisiae and higher eukaryotes share many structural and functional similarities, we investigated subcellular effects of NP on S.cerevisiae BY4742 cells by analyzing genome-wide transcriptional profiles. We examined effects of low (1 mg/l; <15% cell number reduction) and high (5 mg/l; > 65% cell number reduction) inhibitory concentration exposures for 120 or 180 min. After 120 and 180 min of 1 mg/l NP exposure, 187 (63 downregulated, 124 upregulated) and 103 genes (56 downregulated, 47 upregulated), respectively, were differentially expressed. Similarly, 678 (168 repressed, 510 induced) and 688 genes (215 repressed, 473 induced) were differentially expressed in cells exposed to 5 mg/l NP for 120 and 180 min, respectively. Only 15 downregulated and 63 upregulated genes were common between low and high NP inhibitory concentration exposure for 120 min, whereas 16 downregulated and 31 upregulated genes were common after the 180-min exposure. Several processes/pathways were prominently affected by either low or high inhibitory concentration exposure, while certain processes were affected by both inhibitory concentrations, including ion transport, response to chemicals, transmembrane transport, cellular amino acids, and carbohydrate metabolism. While minimal expression changes were observed with low inhibitory concentration exposure, 5 mg/l NP treatment induced substantial expression changes in genes involved in oxidative phosphorylation, cell wall biogenesis, ribosomal biogenesis, and RNA processing, and encoding heat shock proteins and ubiquitin-conjugating enzymes. Collectively, these results provide considerable information on effects of NP at the molecular level.en_US
dc.description.sponsorshipMarmara University Scientific Research CommissionMarmara University [FEN-A-120613-0268, FEN-C-DRP-121214-0385]en_US
dc.description.sponsorshipThis research was supported by the Marmara University Scientific Research Commission through projects FEN-A-120613-0268 and FEN-C-DRP-121214-0385.en_US
dc.language.isoengen_US
dc.publisherAmer Physiological Socen_US
dc.relation.ispartofPhysiological Genomicsen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectnonylphenolen_US
dc.subjectgenome-wide transcriptional profilesen_US
dc.subjectSaccharomyces cerevisiaeen_US
dc.subjectexposureen_US
dc.subjectdownregulationen_US
dc.subjectupregulationen_US
dc.titleGenome reprogramming in Saccharomyces cerevisiae upon nonylphenol exposureen_US
dc.typearticleen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.description.wospublicationidWOS:000412393600003en_US
dc.description.scopuspublicationid2-s2.0-85030660571en_US
dc.departmentGümüşhane Üniversitesien_US
dc.authoridMertoglu, Bulent / 0000-0001-6827-3791
dc.authoridArga, Kazim Yalcin / 0000-0002-6036-1348
dc.authoridBereketoglu, Ceyhun / 0000-0001-9400-7892
dc.authoridEraslan, Serpil / 0000-0002-7674-7384
dc.identifier.volume49en_US
dc.identifier.issue10en_US
dc.identifier.startpage549en_US
dc.identifier.doi10.1152/physiolgenomics.00034.2017
dc.identifier.endpage566en_US
dc.authorwosidMertoglu, Bulent / AAB-2374-2021
dc.authorwosidbereketoglu, ceyhun / AAD-9508-2019
dc.authorwosidArga, Kazim Yalcin / Z-3711-2019
dc.authorscopusid55358498200
dc.authorscopusid6506016742
dc.authorscopusid6602691994
dc.authorscopusid6508095432
dc.description.pubmedpublicationidPubMed: 28887370en_US


Bu öğenin dosyaları:

DosyalarBoyutBiçimGöster

Bu öğe ile ilişkili dosya yok.

Bu öğe aşağıdaki koleksiyon(lar)da görünmektedir.

Basit öğe kaydını göster