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dc.contributor.authorMentese, A.
dc.contributor.authorAlver, A.
dc.contributor.authorDemir, S.
dc.contributor.authorSumer, A.
dc.contributor.authorYaman S, Ozer
dc.contributor.authorKarkucak, M.
dc.contributor.authorTuran, I
dc.date.accessioned2021-11-09T19:50:14Z
dc.date.available2021-11-09T19:50:14Z
dc.date.issued2017
dc.identifier.issn0303-464X
dc.identifier.urihttps://hdl.handle.net/20.500.12440/4221
dc.description.abstractBackground: Behcet's disease ( BD) is a vasculitis, seen more frequently around the Mediterranean and the Far East, and evinces with oral and genital ulcerations, skin lesions and uveitis. Carbonic anhydrase ( CA) is a metalloenzyme which is widely distributed in the living world, and it is essential for the regulation of acid-base balance. Anti-CA antibodies have been reported in many disorders, such as systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, endometriosis, idiopathic chronic pancreatitis, type 1 diabetes and Graves' disease. The goal of this study was to investigate CA I and II autoantibodies in BD. Methods: 35 patients with BD and 29 healthy controls were included in the study and CA I and II autoantibody levels were investigated by ELISA. Results: The CA I and II autoantibody levels of BD group were significantly higher than the healthy group (p= 0.013, p= 0.0001, respectively). A cut-off value of 0.250 absorbance unit (ABSU) for anti-CA I was associated with 34% sensitivity and 100% specificity and a cut-off value of 0.171 ABSU for anti-CA II was associated with 54% sensitivity and 100% specificity for predicting BD. Conclusion: The CA I and II autoantibody levels in pa-tients with BD were found higher compared to control group and the results suggest that CA I and II autoantibodies may be involved in the pathogenesis of BDen_US
dc.language.isoengen_US
dc.publisherPublisaude-Edicoes Medicas Ldaen_US
dc.relation.ispartofActa Reumatologica Portuguesaen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutoantibodyen_US
dc.subjectBehcet's diseaseen_US
dc.subjectCarbonic anhydraseen_US
dc.titleCarbonic anhydrase I and II autoantibodies in Behcet's diseaseen_US
dc.typearticleen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.description.wospublicationidWOS:000398616200004en_US
dc.departmentGümüşhane Üniversitesien_US
dc.authoridDemir, Selim / 0000-0002-1863-6280
dc.authoridALVER, AHMET / 0000-0002-9617-6689
dc.identifier.volume42en_US
dc.identifier.issue1en_US
dc.identifier.startpage26en_US
dc.identifier.endpage31en_US
dc.authorwosidDemir, Selim / AAE-8473-2020
dc.authorwosidDemir, Selim / AAR-2241-2020
dc.authorwosidALVER, AHMET / AAH-4599-2021
dc.authorwosidTuran, Ibrahim / ABI-5207-2020
dc.authorwosidMentese, Ahmet / AAT-2342-2020
dc.description.pubmedpublicationidPubMed: 28198796en_US


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