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In vitro inhibition of alpha-carbonic anhydrase isozymes by some phenolic compounds

dc.contributor.authorSarikaya, Sevim Beyza Ozturk
dc.contributor.authorTopal, Fevzi
dc.contributor.authorSenturk, Murat
dc.contributor.authorGulcin, Ilhami
dc.contributor.authorSupuran, Claudiu T.
dc.date.accessioned2021-11-09T19:49:54Z
dc.date.available2021-11-09T19:49:54Z
dc.date.issued2011
dc.identifier.issn0960-894X
dc.identifier.issn1464-3405
dc.identifier.urihttps://doi.org/10.1016/j.bmcl.2011.05.071
dc.identifier.urihttps://hdl.handle.net/20.500.12440/4151
dc.description.abstractCarbonic anhydrase inhibitors (CAIs) are a class of pharmaceuticals used as antiglaucoma agents, diuretics, antiepileptics, in the management of mountain sickness, gastric and duodenal ulcers, neurological disorders or osteoporosis. We report here the inhibitory capacities of some phenolic compounds against three human CA isozymes (hCA I, hCA II, and hCA VI) and the gill carbonic anhydrase of the teleost fish Dicentrarchus labrax (European seabass) (dCA). The isozymes showed quite diverse inhibition profiles with these compounds. These data may lead to design novel CAIs with a diverse inhibition mechanism compared to sulfonamide/sulfamate inhibitors. (C) 2011 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipTurkish Republic Prime Ministry State Planning Organization (DPT)Turkiye Cumhuriyeti Kalkinma Bakanligi [2010K120440]; Agri Ibrahim Cecen University Scientific Research CouncilAgri Ibrahim Cecen University [Agri BAP-2010/K-10]en_US
dc.description.sponsorshipThis study was financed by Turkish Republic Prime Ministry State Planning Organization (DPT), (Project no: 2010K120440) for (M.S. and I.G.) and Agri Ibrahim Cecen University Scientific Research Council (Project No: Agri BAP-2010/K-10) for (M.S.).en_US
dc.language.isoengen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofBioorganic & Medicinal Chemistry Lettersen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTannic aciden_US
dc.subjectPyrogallolen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectInhibitionen_US
dc.subjecthCA-Ien_US
dc.subjecthCA-IIen_US
dc.subjecthCA VIen_US
dc.subjectdCAen_US
dc.subjectAntiglaucomaen_US
dc.titleIn vitro inhibition of alpha-carbonic anhydrase isozymes by some phenolic compoundsen_US
dc.typearticleen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.description.wospublicationidWOS:000292186400030en_US
dc.description.scopuspublicationid2-s2.0-79959902277en_US
dc.departmentGümüşhane Üniversitesien_US
dc.authoridGULCIN, Ilhami / 0000-0001-5993-1668
dc.authoridSenturk, Murat / 0000-0001-5968-7511
dc.authoridSupuran, Claudiu / 0000-0003-4262-0323
dc.identifier.volume21en_US
dc.identifier.issue14en_US
dc.identifier.startpage4259en_US
dc.identifier.doi10.1016/j.bmcl.2011.05.071
dc.identifier.endpage4262en_US
dc.authorwosidGULCIN, Ilhami / F-1428-2014
dc.authorwosidSupuran, Claudiu T / A-5151-2008
dc.authorwosidSenturk, Murat / C-4491-2012
dc.authorscopusid39262128900
dc.authorscopusid35811768400
dc.authorscopusid23013520200
dc.authorscopusid35509141500
dc.authorscopusid7102904152
dc.description.pubmedpublicationidPubMed: 21669522en_US


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