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N-Acylsulfonamides strongly inhibit human carbonic anhydrase isoenzymes I and II

dc.contributor.authorYildirim, Alper
dc.contributor.authorAtmaca, Ufuk
dc.contributor.authorKeskin, Ali
dc.contributor.authorTopal, Meryem
dc.contributor.authorCelik, Murat
dc.contributor.authorGulcin, Ilhami
dc.contributor.authorSupuran, Claudiu T.
dc.date.accessioned2021-11-09T19:49:35Z
dc.date.available2021-11-09T19:49:35Z
dc.date.issued2015
dc.identifier.issn0968-0896
dc.identifier.issn1464-3391
dc.identifier.urihttps://doi.org/10.1016/j.bmc.2014.12.054
dc.identifier.urihttps://hdl.handle.net/20.500.12440/4077
dc.description.abstractSulfonamides represent a significant class of biologically active compounds that inhibit carbonic anhydrase (CA, EC.: 4.2.1.1) isoenzymes involved in different pathological and physiological events. Sulfonamide CA inhibitors are used therapeutically as diuretic, antiglaucoma, antiobesity and anticancer agents. A series of new sulfonamides were synthesized using imides and tosyl chloride as starting materials. These N-acylsulfonamides efficiently inhibited the cytosolic human carbonic anhydrase isoenzymes I, and II (hCA I, and II), with nanomolar range inhibition constants ranging between 36.4 +/- 6.0-254.6 +/- 18.0 and 58.3 +/- 0.6-273.3 +/- 2.5 nM, respectively. (C) 2015 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipAtaturk UniversityAtaturk University [TUBITAK 110T483]; Research Chairs Program at King Saud Universityen_US
dc.description.sponsorshipThis study was financed by Ataturk University (TUBITAK 110T483). Additionally, Ilhami Gulcin would like to extend his sincere appreciation to the Research Chairs Program at King Saud University for funding this research.en_US
dc.language.isoengen_US
dc.publisherPergamon-Elsevier Science Ltden_US
dc.relation.ispartofBioorganic & Medicinal Chemistryen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectSulfonamideen_US
dc.subjectImideen_US
dc.subjectN-Acylsulfonamideen_US
dc.subjectCarbonic anhydraseen_US
dc.subjectEnzyme purificationen_US
dc.subjectEnzyme inhibitionen_US
dc.titleN-Acylsulfonamides strongly inhibit human carbonic anhydrase isoenzymes I and IIen_US
dc.typearticleen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.description.wospublicationidWOS:000353380400029en_US
dc.description.scopuspublicationid2-s2.0-84937765332en_US
dc.departmentGümüşhane Üniversitesien_US
dc.authoridGULCIN, Ilhami / 0000-0001-5993-1668
dc.authoridATMACA, Ufuk / 0000-0002-5598-0443
dc.authoridSupuran, Claudiu / 0000-0003-4262-0323
dc.identifier.volume23en_US
dc.identifier.issue10en_US
dc.identifier.startpage2598en_US
dc.identifier.doi10.1016/j.bmc.2014.12.054
dc.identifier.endpage2605en_US
dc.authorwosidKeskin, Ali / AAZ-8763-2020
dc.authorwosidyildirim, Alper / ABI-3876-2020
dc.authorwosidkeskin, ali / ABC-8286-2020
dc.authorwosidGULCIN, Ilhami / F-1428-2014
dc.authorwosidATMACA, Ufuk / AAU-8138-2020
dc.authorwosidAtmaca, Ufuk / AAB-2504-2019
dc.authorscopusid56489873600
dc.authorscopusid35145213300
dc.authorscopusid56157763100
dc.authorscopusid55929192400
dc.authorscopusid7101855316
dc.authorscopusid35509141500
dc.authorscopusid7102904152
dc.description.pubmedpublicationidPubMed: 25863492en_US


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