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The effect of homocysteine on the expression of CD36, PPAR gamma, and C/EBP alpha in adipose tissue of normal and obese mice

dc.contributor.authorMentese, Ahmet
dc.contributor.authorDogramaci, Seniz
dc.contributor.authorDemir, Selim
dc.contributor.authorYaman, Serap Ozer
dc.contributor.authorInce, Imran
dc.contributor.authorAltay, Diler Us
dc.contributor.authorAlver, Ahmet
dc.date.accessioned2021-11-09T19:49:26Z
dc.date.available2021-11-09T19:49:26Z
dc.date.issued2021
dc.identifier.issn1381-3455
dc.identifier.issn1744-4160
dc.identifier.urihttps://doi.org/10.1080/13813455.2019.1648517
dc.identifier.urihttps://hdl.handle.net/20.500.12440/4038
dc.description.abstractThe purpose of this study was to investigate the effect of homocysteine (Hcy) on CD36, PPAR gamma, and C/EBP alpha gene and protein expression in adipose tissue obtained from normal and high-calorie diet obesity models. CD36, PPAR gamma, and C/EBP alpha gene expression and protein levels in adipose tissue specimens were determined using the RT-PCR and ELISA methods, respectively. Significantly increased CD36 gene expression was observed in adipose tissue from obese mice, while Hcy significantly reduced CD36 gene expression in adipose tissue from normal and obese mice. PPAR gamma and C/EBP alpha gene expression levels decreased significantly in all groups compared to the normal group. In addition, levels of both PPAR gamma and C/EBP alpha gene expression were lower with Hcy supplementation compared to their own controls. In conclusion, Hcy's reduction of CD36 gene expression in adipose tissue may be one probable factor in hyperhomocysteinemia representing an independent risk factor for cardiovascular diseases.en_US
dc.description.sponsorshipKaradeniz Technical University Scientific Research FoundationKaradeniz Technical University [5323]en_US
dc.description.sponsorshipThis study has been supported by Karadeniz Technical University Scientific Research Foundation with the project number 5323.en_US
dc.language.isoengen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofArchives of Physiology and Biochemistryen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAdipose tissueen_US
dc.subjectcardiovascular diseasesen_US
dc.subjectCD36en_US
dc.subjectCen_US
dc.subjectEBP alphaen_US
dc.subjecthyperhomocysteinemiaen_US
dc.subjectobesityen_US
dc.subjectPPAR gammaen_US
dc.titleThe effect of homocysteine on the expression of CD36, PPAR gamma, and C/EBP alpha in adipose tissue of normal and obese miceen_US
dc.typearticleen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.description.wospublicationidWOS:000480150000001en_US
dc.description.scopuspublicationid2-s2.0-85116166089en_US
dc.departmentGümüşhane Üniversitesien_US
dc.authoridERDEM, Mehmet / 0000-0002-9100-2479
dc.authoridALVER, AHMET / 0000-0002-9617-6689
dc.authoridDemir, Selim / 0000-0002-1863-6280
dc.authoridDOGRAMACI, SENIZ / 0000-0001-5643-3057
dc.authoridus altay, diler / 0000-0002-0465-8403
dc.authoridTURAN, IBRAHIM / 0000-0003-3400-5494
dc.identifier.volume127en_US
dc.identifier.issue5en_US
dc.identifier.startpage437en_US
dc.identifier.doi10.1080/13813455.2019.1648517
dc.identifier.endpage444en_US
dc.authorwosidERDEM, Mehmet / AAN-5283-2021
dc.authorwosidALVER, AHMET / AAH-4599-2021
dc.authorwosidDemir, Selim / AAR-2241-2020
dc.authorwosidDOGRAMACI, SENIZ / AAR-2145-2020
dc.authorwosidMentese, Ahmet / AAT-2342-2020
dc.authorwosidDemir, Selim / AAE-8473-2020
dc.authorscopusid23489347700
dc.authorscopusid57197811025
dc.authorscopusid55674801800
dc.authorscopusid56747555600
dc.authorscopusid57188686227
dc.authorscopusid55538314800
dc.authorscopusid57202648027
dc.description.pubmedpublicationidPubMed: 31373231en_US


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