Kimya ve Kimyasal İşleme Teknolojileri Bölümü Koleksiyonu
https://hdl.handle.net/20.500.12440/81
2024-03-28T22:45:17ZDesign and Synthesis of Pyrazole Carboxamide Derivatives as Selective Cholinesterase and Carbonic Anhydrase Inhibitors: Molecular Docking and Biological Evaluation
https://hdl.handle.net/20.500.12440/6126
Design and Synthesis of Pyrazole Carboxamide Derivatives as Selective Cholinesterase and Carbonic Anhydrase Inhibitors: Molecular Docking and Biological Evaluation
Mustafa Durgun; Suleyman Akocak; Nebih Lolak; Fevzi Topal; Ümit Muhammet Koçyiğit; Cüneyt Türkeş; Mesut Işık; Şükrü Beydemir
The present study focused on the synthesis and characterization of novel pyrazole carboxamide derivatives (SA1-12). The inhibitory effect of the compounds on cholinesterases (ChEs; AChE and BChE) and carbonic anhydrases (hCAs; hCA I and hCA II) isoenzymes were screened as in vitro. These series compounds have been identified as potential inhibitors with a KI values in the range of 10.69 ± 1.27-70.87 ± 8.11 nM for hCA I, 20.01 ± 3.48- 56.63 ± 6.41 nM for hCA II, 6.60 ± 0.62-14.15 ± 1.09 nM for acetylcholinesterase (AChE) and 54.87 ± 7.76-137.20 ±9.61 nM for butyrylcholinesterase (BChE). These compounds have a more effective inhibition effect when compared to the reference compounds. In addition, the potential binding positions of the compounds with high affinity for ChE and hCAs were demonstrated by in silico methods. The results of in silico and in vitro studies support each other. As a result of the present study, the compounds with high inhibitory activity for metabolic enzymes, such as ChE and hCA were designed. The compounds may be potential alternative agents used as selective ChE and hCA inhibitors in the treatment of Alzheimer's disease and glaucoma.
2023-01-01T00:00:00ZA green and simplified approach for the quantitative and sensitive analysis of heavy metal ions in sea and stream waters
https://hdl.handle.net/20.500.12440/6102
A green and simplified approach for the quantitative and sensitive analysis of heavy metal ions in sea and stream waters
Duran, Celal; Camoglu, Aslihan Yilmaz; Ozdes, Duygu; Bekircan, Olcay
Elimination of the matrix effect is a major challenge in developing a method for the quantification of heavy metals (HMs) in water samples. In this regard, the current research describes the simultaneous analyses of Cu(II), Cd(II), and Ni(II) ions in water matrices through flame atomic absorption spectrophotometry (FAAS) after preconcentration with carrier element-free co-precipitation (CEFC) technique by the help of an organic co-precipitant, 3-{[5-(4-Chlorobenzyl)-3-(4-chlorophenyl)-1H-1,2,4-triazol-1-yl]-methyl}-4-[2,4-(dichlorobenzylidene)amino]-1H-1,2,4-triazole-5(4H)-thione (CCMBATT). Based on our literature research, CCMBATT was employed for the first time in this study as an organic co-precipitant for the preconcentration of HMs. Factors such as solution pH, concentration of co-precipitant, sample volume, standing time, centrifugation rate, and time were thoroughly examined and optimized to achieve the highest efficiency in terms of HM recovery. The limits of detection (LODs) (with 10 number of tests) of 0.54, 0.34, and 1.95 mu g L-1 and the relative standard deviations (RSD %) of 2.1, 3.3, and 3.0 were determined for Cu(II), Cd(II) and Ni(II) ions, respectively. Recovery results of HMs for the spiked samples were in the range of 92.8-101.0%, demonstrating the trueness of the method and its applicability to the water samples matrix.
2023-01-01T00:00:00ZAdsorptive removal of Cr(VI) and Cu(II) ions from aqueous solutions by a natural moss
https://hdl.handle.net/20.500.12440/6082
Adsorptive removal of Cr(VI) and Cu(II) ions from aqueous solutions by a natural moss
Ozeken, Sengul Tugba; Ozdes, Duygu; Duran, Celal
The aim of the present research is to develop a new, fast, and easily applicable adsorption method for the removal of hazardous Cr(VI) and Cu(II) ions from the polluted industrial wastewater by using Racomitrium ericoides (Brid.) Brid. (REB), a type of moss. Although there are studies in the literature in which different moss species were used for the removal of heavy metals (HMs), REB was used for the first time in this study. Adsorption experiments were carried out through a batch system. The impact of significant experimental parameters showed that the optimum values of initial pH were 2.0 for Cr(VI) retention and 5.0 for Cu(II), and 360 min was selected as the optimum contact time for both HMs. An artificial neural network (ANN) model was applied to create a predictive model for the uptake efficiency of HMs. Adsorption kinetics of Cr(VI) and Cu(II) ions followed the pseudo-second order model. The maximum adsorption capacities of REB identified through the Langmuir model were 41.2 mg g(-1) for Cr(VI) and 22.7 mg g(-1 )for Cu(II) ions. The results of the study demonstrated that REB can be utilized as an abundant, low-cost, and effective adsorbent in removal of HMs from aqueous solutions.HIGHLIGHTS center dot Racomitrium ericoides (Brid.) Brid. (REB) was used for first time as a low-cost and efficient adsorbent for the removal of heavy metal ions from aqueous media.center dot An economical and promising adsorbent was developed for industrial wastewater treatment applications.center dot REB has higher adsorption capacity than many other expensive adsorbents used for the removal of Cr(VI) and Cu(II) in the literature.
2023-01-01T00:00:00ZGreen synthesis of fluorescent carbon dots from Robinia hispida L. leaves for selective detection of Hg (II)
https://hdl.handle.net/20.500.12440/6040
Green synthesis of fluorescent carbon dots from Robinia hispida L. leaves for selective detection of Hg (II)
Başoğlu, Aysel
In this study, Robinia hispida L. leaves (RH) was used as a precursor for the first time to synthesize fluorescent carbon dots (CDs) with stable blue fluorescence by a single-step hydrothermal synthesis method. Notably, the innovative approach eliminates the necessity for toxic chemicals or hazardous substances, marking a significant advancement in the field. The synthesized CDs demonstrate CDs demonstrates the predominance of spherical shapes with an average size of 11.63 ± 1.92 nm. The CDs not only exhibit an enhanced fluorescent efficiency with a relatively high quantum yield of up to 6.8%, but they also possess the potential for direct utilization in the selective determination of Hg(II) through fluorescence quenching, even without any functionalization. Under the optimized conditions at a pH of 7.0, a robust linear correlation was found to exist between the fluorescence intensity and the concentration of Hg (II) within the range of 5 - 17.5 µM, exhibiting a detection limit (3σ) of 1.5 µM. Additionally, this methodology was effectively employed to successfully detect Hg (II) ions in various aqueous samples, including tap water, spring water, drinking water, and a certified reference material (CRM-SA-C Sandy Soil C). The spike recoveries of 97.6%-101.6% with less than 2.7% variability were performed on all sample
2023-01-01T00:00:00Z